REAL TALK ABOUT
AUTOIMMUNE T1D AND TZIELD

TZIELD is indicated to delay onset of Stage 3 type 1 diabetes (T1D) for people 8 years and older with Stage 2 T1D.

Will, TZIELD patient with caregiver
Will, a TZIELD® (teplizumab-mzwv) patient, holding a small dog while walking outdoors with his mother and caregiver, Amanda

Watch real stories from real people

Watch our collection of videos, filled with real talk from real people about living well* with autoimmune type 1 diabetes and what TZIELD has meant to them.

*Individual results may vary.

John’s Story

Always active, John was stunned when he was told he had type 2 diabetes. Despite diet and exercise, his condition continued to decline. John decided to get a second opinion, and learned he was actually in Stage 2 of type 1 diabetes. For the first time there was a treatment option: TZIELD.

John is a Patient Ambassador sponsored by Sanofi.

TZIELD Indication for :15 seconds

I am being compensated by Sanofi to share my story.

On-Screen Disclaimer:
John is being compensated for sharing his story in this video.

John is a TZIELD patient. Individual results may vary. Please see Important Safety Information at the conclusion of this video and full Prescribing Information/Medication Guide on the webpage.

I don't need an alarm clock. My day starts at 6:15 A.M. and it's usually the sound of my son's voice, Johnny, saying, "Dad, mom, I'm ready to get up." And so that's the beginning of my day.

Family's important to me. That's where I spend a lot of my time. The weekends are all about going to various activities.

On September 7th, 2022, three days before the birth of my second son, Leo, I was misdiagnosed with type two diabetes.

On-Screen Disclaimer:
Patient stories reflect the real-life experiences of persons diagnosed with Stage 2 T1D who have been prescribed TZIELD. However, individual experiences may vary. Patient stories are not necessarily representative of what another person using TZIELD may experience.

I had gone for some routine blood work. I didn't have any symptoms or anything like that. I remember when I got the blood work back and I spoke with the nurse practitioner and she told me, “John, your numbers are terrible, and you have type two diabetes.” And I remember just being stunned because I didn't know anything about diabetes.

I have no family history of type one or type two diabetes. I've been very active in my life, so to hear this news, it took me completely by surprise.

She told me that I was going to have to eat better and exercise more.

It did not occur to me to question my type two diagnosis. I took it upon myself to realize, "Hey, this is something that I can control and if I control my diet and exercise, I can resolve this."

Within three months, my A1C was down considerably. And I was like, “Hey, I did it. I knocked it out. It’s going to be smooth from now on. I know what I need to do.”

The ability to use my exercise and nutrition was short-lived. After that first A1C in which I was able to get it down, it seemed like no matter what I was doing, that I wasn't able to have the same control that I had had in those first three months.

I was getting frustrated with the results that I was having. So one day, I called my brother-in-law who’s a doctor in Omaha, Nebraska, and I asked him what I should do and I told him my story. And he told me, “John, it’s time to get a second opinion.”

And so, six months to the day of my misdiagnosis with type 2 diabetes, I made that call to a primary care physician.

The doctor tested me for type one diabetes-related autoantibodies. I tested positive for multiple, and I had high glycemic levels. And that proved that I was actually in stage two type 1 diabetes.

I remember asking, "Is there anything that I can do treatment-wise for my type one diabetes?" And I remember her saying, "I think you might be a good candidate for this TZIELD.”

On-Screen Indication

What is TZIELD?

TZIELD is a prescription medicine used to delay the onset of Stage 3 type 1 diabetes, which is when your body can’t make enough insulin on its own and may require insulin injections. TZIELD is for adults and children 8 years of age and older who have Stage 2 type 1 diabetes. This means that they have tested positive for 2 or more type 1 diabetes-related autoantibodies, have abnormal blood sugar levels and do not have type 2 diabetes. It is not known if TZIELD is safe and effective in children under 8 years of age.

I was really excited about it because I had done some research and thought maybe this might be an option for me.

In my follow up conversation with my endocrinologist, I asked her about side effects.

My doctor explained that the most common side effects were rash, leukopenia, which is a decrease in white blood cell count, and headache. I also learned that Tzield may cause serious side effects, including cytokine release syndrome and lymphopenia, which is a decrease in white blood cells.

On-Screen Disclaimer:
The most common side effects of TZIELD include rash, leukopenia (decrease in white blood cell counts) and headache. TZIELD may cause serious side effects, including cytokine release syndrome and lymphopenia, which is a decrease in white blood cells.

I learned that TZIELD would take place over 14 days with daily infusions.

On-Screen Disclaimer:
Your healthcare provider will do blood tests to check your liver and your complete blood counts before you start treatment and during treatment with TZIELD.

I knew this wasn’t a cure, but that it could delay the onset of stage 3 type 1 diabetes when insulin is needed. I was the first person in my endocrinologist's clinic to go on TZIELD, so it took a little bit of time to get things going.

Fortunately, I visited the TZIELD website and got connected with the COMPASS Navigator program. Within a day of me reaching out, I had a phone conversation with a Navigator and she was so helpful. She was able to explain to me about the process, help me understand the paperwork needed, got connected with my endocrinologist clinic and helped me understand the timelines of what things looked like next.

I had my first Tzield treatment on August 18th, 2023.

On-Screen Disclaimer:
TZIELD is given by a healthcare provider through a needle placed in a vein (intravenous infusion) in your arm.

On-Screen:
For the first 5 days of treatment, your healthcare provider will give you medicines by mouth before starting your TZIELD infusion. These medicines include ibuprofen, naproxen or other pain relievers such as acetaminophen, an antihistamine, and an anti-nausea medicine. These medicines may help reduce symptoms of cytokine release syndrome (CRS) such as a fever, headache, muscle and joint pain, or nausea.

During the first five or six days, I did feel a little more tired than usual.

I also had some nausea after day five or six, and I also experienced the rash.

My oldest son came by for one of the infusions, so it was a chance for me to share with him what was going on for my infusions. So that was a special time for us.

On-Screen:
Individual results may vary.

In terms of the TZIELD results, for me, this meant more time for me to get comfortable with the idea of this diagnosis, be able to understand my body a little bit more and get comfortable with the idea of one day having to go on insulin.

Full indication and ISI with voiceover


©2024 Sanofi. All rights reserved. MAT-US-2403654-v1.0-06/2024
Intended for U.S. residents only.

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SEE ALLSEE LESS

Share your TZIELD story

Your experience with TZIELD is one-of-a-kind. By sharing your journey through, screening, diagnosis, and treatment as a TZIELD Patient Ambassador, you can make a difference in the lives of patients and caregivers in Stage 2 of autoimmune type 1 diabetes who are about to start their TZIELD journey. Please self-nominate by emailing us at T1Dstories@vprpop.com or calling 855-212-4267.

IMPORTANT SAFETY INFORMATION What is the most important information I should know about TZIELD? TZIELD may cause serious side effects. These include:
  • Cytokine release syndrome (CRS). Signs and symptoms may start during the first 5 days of TZIELD treatment and could include fever, nausea, feeling tired (fatigue), headache, muscle and joint pain, or increased liver enzymes in your blood. Tell your healthcare provider right away if you develop any signs and symptoms of CRS during treatment with TZIELD
  • Decrease in white blood cells. TZIELD may cause a decrease in a type of white blood cell called lymphocytes. A decrease in white blood cells is a serious, but common side effect that can affect your body’s ability to fight infections. A decrease in white blood cell counts can happen after your first dose. Your white blood cell counts will start to go back to normal after your fifth dose of TZIELD. Some people may develop longer and more severe decreases in lymphocytes

Your healthcare provider will do blood tests to check your liver and your complete blood counts before you start treatment and during treatment with TZIELD. During and after your treatment with TZIELD, your healthcare provider will check for serious side effects, as well as other side effects, and treat you as needed. Your healthcare provider may temporarily or completely stop your treatment with TZIELD, if you develop liver problems, have a serious infection, or if your blood counts stay too low.

What should I tell my healthcare provider before receiving TZIELD? Before or after receiving TZIELD, tell your healthcare provider about all your medical conditions, including if you:
  • have a serious infection or an infection that does not go away or keeps coming back
  • have recently received or are scheduled to receive an immunization (vaccine). TZIELD may affect how well a vaccine works. Tell your doctor that you are receiving TZIELD before receiving a vaccine
  • are pregnant or plan to become pregnant. TZIELD may harm your unborn baby. Do not receive TZIELD during pregnancy and at least 30 days before a planned pregnancy
  • are breastfeeding or plan to breastfeed. It is not known if TZIELD passes into your breast milk and if it can harm your baby. Talk to your healthcare provider about the best way to feed your baby if you receive TZIELD

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of TZIELD? The most common side effects of TZIELD include:
  • rash
  • leukopenia (decrease in white blood cell counts)
  • headache

These are not all of the possible side effects of TZIELD. Talk to your healthcare provider for more information, and tell them about any side effects you notice. You may report side effects to the FDA at www.fda.gov/medwatch or 1-800-FDA-1088.

Please see Medication Guide and Prescribing Information.

What is TZIELD?

TZIELD is a prescription medicine used to delay the onset of Stage 3 type 1 diabetes, which is when your body can’t make enough insulin on its own and may require insulin injections. TZIELD is for adults and children 8 years of age and older who have Stage 2 type 1 diabetes. This means that they have tested positive for 2 or more type 1 diabetes-related autoantibodies, have abnormal blood sugar levels, and do not have type 2 diabetes.

It is not known if TZIELD is safe and effective in children under 8 years of age.

IMPORTANT SAFETY INFORMATION AND APPROVED USE

What is the most important information I should know about TZIELD? TZIELD may cause serious side effects. These include:
  • Cytokine release syndrome (CRS). Signs and symptoms may start during the first 5 days of TZIELD treatment and could include fever, nausea, feeling tired (fatigue), headache, muscle and joint pain, or increased liver enzymes in your blood. Tell your healthcare provider right away if you develop any signs and symptoms of CRS during treatment with TZIELD
  • Decrease in white blood cells. TZIELD may cause a decrease in a type of white blood cell called lymphocytes. A decrease in white blood cells is a serious, but common side effect that can affect your body’s ability to fight infections. A decrease in white blood cell counts can happen after your first dose. Your white blood cell counts will start to go back to normal after your fifth dose of TZIELD. Some people may develop longer and more severe decreases in lymphocytes

Your healthcare provider will do blood tests to check your liver and your complete blood counts before you start treatment and during treatment with TZIELD. During and after your treatment with TZIELD, your healthcare provider will check for serious side effects, as well as other side effects, and treat you as needed. Your healthcare provider may temporarily or completely stop your treatment with TZIELD, if you develop liver problems, have a serious infection, or if your blood counts stay too low.

What should I tell my healthcare provider before receiving TZIELD? Before or after receiving TZIELD, tell your healthcare provider about all your medical conditions, including if you:
  • have a serious infection or an infection that does not go away or keeps coming back
  • have recently received or are scheduled to receive an immunization (vaccine). TZIELD may affect how well a vaccine works. Tell your doctor that you are receiving TZIELD before receiving a vaccine
  • are pregnant or plan to become pregnant. TZIELD may harm your unborn baby. Do not receive TZIELD during pregnancy and at least 30 days before a planned pregnancy
  • are breastfeeding or plan to breastfeed. It is not known if TZIELD passes into your breast milk and if it can harm your baby. Talk to your healthcare provider about the best way to feed your baby if you receive TZIELD

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of TZIELD? The most common side effects of TZIELD include:
  • rash
  • leukopenia (decrease in white blood cell counts)
  • headache

These are not all of the possible side effects of TZIELD. Talk to your healthcare provider for more information, and tell them about any side effects you notice. You may report side effects to the FDA at www.fda.gov/medwatch or 1-800-FDA-1088.

Please see Medication Guide and Prescribing Information.

What is TZIELD?

TZIELD is a prescription medicine used to delay the onset of Stage 3 type 1 diabetes, which is when your body can’t make enough insulin on its own and may require insulin injections. TZIELD is for adults and children 8 years of age and older who have Stage 2 type 1 diabetes. This means that they have tested positive for 2 or more type 1 diabetes-related autoantibodies, have abnormal blood sugar levels, and do not have type 2 diabetes.

It is not known if TZIELD is safe and effective in children under 8 years of age.