Treatment with TZIELD
TZIELD has changed the possibilities of autoimmune type 1 diabetes treatment
If a doctor decides TZIELD is right for you or your loved one, taking action now with 2 weeks of treatment with TZIELD could mean more time in Stage 2 type 1 diabetes for patients 8 years and older, when daily insulin injections are not yet needed.
Treatment with TZIELD could mean:
- More time without the need for insulin injections
- More time to learn about eventual symptoms and risks
- More time to get ready for daily insulin management.
HERE'S WHAT YOU CAN EXPECT FROM TREATMENT WITH TZIELD:
TZIELD is an intravenous (IV) infusion.
This means it's given through a needle in your arm. TZIELD infusions are given once a day, for 14 days in a row, and take at least 30 minutes plus setup and monitoring time. TZIELD is a one-time treatment.
14 days
At least 30 minutes long
You will also need some extra time before and after each infusion so a nurse can prepare the infusion and monitor you or your loved one for a short period afterward.
If a scheduled infusion is missed, a doctor will continue the treatment on the next scheduled day. You will not receive 2 infusions on the same day.
Flexible options to receive care
Some infusion locations could include:
At a doctor’s office
At an infusion center
At home with a visiting nurse
or a combination of these options (hybrid)
Talk to your doctor about blood tests
You or your loved one’s doctor will do blood tests to check liver function and complete blood counts before and during treatment with TZIELD.
A TZIELD Compass Navigator
will be there every step of the way
AFTER YOU’RE PRESCRIBED TZIELD, ENROLL IN
The TZIELD COMPASS Support Program
We understand—while TZIELD is a one-time, 14-day treatment, it can seem a bit overwhelming and may require some planning.
Consult your doctor to find a convenient 2-week period for your infusions. When you enroll in the TZIELD COMPASS Support Program, a Navigator can confirm insurance coverage, discuss financial assistance options, and help locate an infusion site for scheduling.
TZIELD COMPASS Support
During the 14 day infusion period
Treatment begins You or your loved one has taken a proactive step to help delay the onset of insulin-dependent type 1 diabetes.
Managing possible infusion reactions Your doctor may prescribe oral medications during your first 5 days of treatment to help mitigate some common side effects such as fever, headache, muscle or joint pain, or nausea. These could include certain types of pain medications, antihistamines, and anti-nausea remedies. They may help reduce symptoms of a possible serious side effect of TZIELD called cytokine release syndrome (CRS), such as fever, headache, muscle/joint pain, or nausea.- Communication is key! TZIELD may cause serious side effects. During and after treatment with TZIELD, your doctor will monitor for serious and other side effects. Side effects may be treated, or the doctor may decide to stop treatment if liver problems or a serious infection develops, or if blood counts stay too low. See Important Safety Information below for more details.
Halfway through! If you miss any infusion days, you may need to continue the next day to complete all 14 infusions.
Treatment is complete! It’s time to celebrate and recognize this accomplishment! Consider contacting TZIELD COMPASS Navigator to share your story. Your experience could inspire others to get screened, staged, and consider TZIELD treatment if diagnosed with Stage 2 T1D.
Follow up with your doctor
The doctor may check in about any side effects or medical conditions after treatment. They can also help work out the right schedule for checking blood sugar levels and for follow-up appointments.
Important Safety Information and Approved Use
What is the most important information I should know about TZIELD? TZIELD may cause serious side effects. These include:- Cytokine release syndrome (CRS). Signs and symptoms may start during the first 5 days of TZIELD treatment and could include fever, nausea, feeling tired (fatigue), headache, muscle and joint pain, or increased liver enzymes in your blood. Tell your healthcare provider right away if you develop any signs and symptoms of CRS during treatment with TZIELD
- Decrease in white blood cells. TZIELD may cause a decrease in a type of white blood cell called lymphocytes. A decrease in white blood cells is a serious, but common side effect that can affect your body’s ability to fight infections. A decrease in white blood cell counts can happen after your first dose. Your white blood cell counts will start to go back to normal after your fifth dose of TZIELD. Some people may develop longer and more severe decreases in lymphocytes
Your healthcare provider will do blood tests to check your liver and your complete blood counts before you start treatment and during treatment with TZIELD. During and after your treatment with TZIELD, your healthcare provider will check for serious side effects, as well as other side effects, and treat you as needed. Your healthcare provider may temporarily or completely stop your treatment with TZIELD, if you develop liver problems, have a serious infection, or if your blood counts stay too low.
What should I tell my healthcare provider before receiving TZIELD? Before or after receiving TZIELD, tell your healthcare provider about all your medical conditions, including if you:- have a serious infection or an infection that does not go away or keeps coming back
- have recently received or are scheduled to receive an immunization (vaccine). TZIELD may affect how well a vaccine works. Tell your doctor that you are receiving TZIELD before receiving a vaccine
- are pregnant or plan to become pregnant. TZIELD may harm your unborn baby. Do not receive TZIELD during pregnancy and at least 30 days before a planned pregnancy
- are breastfeeding or plan to breastfeed. It is not known if TZIELD passes into your breast milk and if it can harm your baby. Talk to your healthcare provider about the best way to feed your baby if you receive TZIELD
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
What are the possible side effects of TZIELD? The most common side effects of TZIELD include:- rash
- leukopenia (decrease in white blood cell counts)
- headache
These are not all of the possible side effects of TZIELD. Talk to your healthcare provider for more information, and tell them about any side effects you notice. You may report side effects to the FDA at www.fda.gov/medwatch or 1-800-FDA-1088.
Please see Medication Guide and Prescribing Information.
What is TZIELD?
TZIELD is a prescription medicine used to delay the onset of Stage 3 type 1 diabetes, which is when your body can’t make enough insulin on its own and may require insulin injections. TZIELD is for adults and children 8 years of age and older who have Stage 2 type 1 diabetes. This means that they have tested positive for 2 or more type 1 diabetes-related autoantibodies, have abnormal blood sugar levels, and do not have type 2 diabetes.
It is not known if TZIELD is safe and effective in children under 8 years of age.
Important Safety Information and Approved Use
- Cytokine release syndrome (CRS). Signs and symptoms may start during the first 5 days of TZIELD treatment and could include fever, nausea, feeling tired (fatigue), headache, muscle and joint pain, or increased liver enzymes in your blood. Tell your healthcare provider right away if you develop any signs and symptoms of CRS during treatment with TZIELD
- Decrease in white blood cells. TZIELD may cause a decrease in a type of white blood cell called lymphocytes. A decrease in white blood cells is a serious, but common side effect that can affect your body’s ability to fight infections. A decrease in white blood cell counts can happen after your first dose. Your white blood cell counts will start to go back to normal after your fifth dose of TZIELD. Some people may develop longer and more severe decreases in lymphocytes
Your healthcare provider will do blood tests to check your liver and your complete blood counts before you start treatment and during treatment with TZIELD. During and after your treatment with TZIELD, your healthcare provider will check for serious side effects, as well as other side effects, and treat you as needed. Your healthcare provider may temporarily or completely stop your treatment with TZIELD, if you develop liver problems, have a serious infection, or if your blood counts stay too low.
What should I tell my healthcare provider before receiving TZIELD? Before or after receiving TZIELD, tell your healthcare provider about all your medical conditions, including if you:- have a serious infection or an infection that does not go away or keeps coming back
- have recently received or are scheduled to receive an immunization (vaccine). TZIELD may affect how well a vaccine works. Tell your doctor that you are receiving TZIELD before receiving a vaccine
- are pregnant or plan to become pregnant. TZIELD may harm your unborn baby. Do not receive TZIELD during pregnancy and at least 30 days before a planned pregnancy
- are breastfeeding or plan to breastfeed. It is not known if TZIELD passes into your breast milk and if it can harm your baby. Talk to your healthcare provider about the best way to feed your baby if you receive TZIELD
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
What are the possible side effects of TZIELD? The most common side effects of TZIELD include:- rash
- leukopenia (decrease in white blood cell counts)
- headache
These are not all of the possible side effects of TZIELD. Talk to your healthcare provider for more information, and tell them about any side effects you notice. You may report side effects to the FDA at www.fda.gov/medwatch or 1-800-FDA-1088.
Please see Medication Guide and Prescribing Information.
What is TZIELD?
TZIELD is a prescription medicine used to delay the onset of Stage 3 type 1 diabetes, which is when your body can’t make enough insulin on its own and may require insulin injections. TZIELD is for adults and children 8 years of age and older who have Stage 2 type 1 diabetes. This means that they have tested positive for 2 or more type 1 diabetes-related autoantibodies, have abnormal blood sugar levels, and do not have type 2 diabetes.
It is not known if TZIELD is safe and effective in children under 8 years of age.