The importance of early screening
Type 1 diabetes has no visible signs or symptoms in its early stages.
Make screening a priority
Finally, type 1 diabetes management is no longer just about waiting until symptoms appear. It's possible for you to stay ahead of what's next.
The American Diabetes Association recommends proactively screening high-risk patients for autoimmune type 1 diabetes with a blood test that can detect it in the early stages.
Screening could help you take action early,
but time is limited.
Undiagnosed insulin-dependent type 1 diabetes could lead to an emergency hospitalization that may have long-term complications for your health.
Autoantibody (AAb) screening is the first step you or your loved one can take to reduce these risks and detect non-symptomatic T1D early and help reduce the risk of life-threatening complications at diagnosis.
If TID is identified at the right time, TZIELD may be a treatment option for appropriate patients because it could delay the onset of symptomatic, insulin-dependent TID.
But the window to treat with TZIELD can be short. Talk to your doctor about AAb screening as the first step to determine whether TZIELD may be right for you.
What is type 1 diabetes screening?
Unlike a blood sugar level test, an autoantibody blood screening looks for early signals of autoimmune type 1 diabetes and is used to determine the risk of developing it.
Screening is often low or even no cost depending on insurance, and knowing there are signs of autoimmune type 1 diabetes lets people act early and proactively seek out monitoring, management, or potential treatment with TZIELD if appropriate.
There are 3 possible screening results:
Zero type 1 diabetes autoantibodies found
What to do: It can be helpful to talk to a doctor about getting rescreened every year, especially with a family history of autoimmune type 1 diabetes.
One type 1 diabetes autoantibody found
What to do: This result means a person is more likely to develop autoimmune type 1 diabetes than someone with no autoantibodies present. Talk to a doctor about monitoring, making sure you have been screened for all 5 autoantibodies, and about a rescreening schedule and next steps.
Two or more type 1 diabetes autoantibodies found
What to do: This result points to the early stages of autoimmune type 1 diabetes. Talk to a doctor about more testing and ask if TZIELD may be an option.
Talk to a doctor about a plan to manage autoimmune type 1 diabetes
How to get screened
There are several ways to get screened for early-stage autoimmune type 1 diabetes:
Screening options for type 1 diabetes
| Screening options for type 1 diabetes | Type 1 Diabetes–Related Autoantibodies | ||||||
|---|---|---|---|---|---|---|---|
| American Diabetes Association Recommended | |||||||
| WHERE TO GET IT | TYPE OF TEST | COST | GADA | IA-2A | IAA | ZnT8A | ICA |
| Doctor’s office or lab* You can get screened at a doctor’s office, or at a lab like Labcorp® or Quest Diagnostics® | Blood draw | Most insurance plans cover some or all of the cost |  | | | | |
| Type 1 diabetes screening central* All US residents can speak with a screening counselor, make a telehealth appointment, or get a screening order or home kit Screenfortype1.com | Blood draw or finger stick | Costs are variable based on services | | | | | Varies depending on |
| Autoimmunity screening via ASK†All U.S. residents can order at-home screening kits online. Residents of Colorado can also get kits at certain screening locations AskHealth.org | Blood draw or finger stick | Free for U.S. residents aged 1 year and older with or without a family history of type 1 diabetes | | | | | |
| Online orderingScreening kits can be ordered by your provider online from vendors like Enable Biosciences | Finger stick | Most insurance plans cover some or all of the cost | | | | ||
| TrialNet‡,§Screening can take place at TrialNet locations, events, or health fairs. You can also receive a screening kit to use at home or to bring in to a Labcorp® or Quest Diagnostics® location TrialNet.org/participate | Blood draw or finger stick | Free for people with a first-degree relative with type 1 diabetes | |  | | | |
These are not all of the screening options available. It’s important to talk to your doctor about the best screening option for you. Inclusion on this list does not imply the endorsement of Sanofi.
*Selection of autoantibody assays are at the HCP’s sole discretion.
†Autoimmunity Screening for Kids.
‡TrialNet will initially test for 2 autoantibodies. If 1 or more autoantibodies are found in the first test, additional testing may be done for other autoantibodies as indicated by the grey check-marked boxes.
§For ages 2.5–45 years old with a first-degree relative and 2.5–20 years old with a second-degree relative.
Remember—screening could help you or a loved one spot autoimmune type 1 diabetes early
A type 1 diagnosis can be a traumatic and sudden experience accompanied by a serious health scare. Early screening could help!
Screening is often available at little or no cost.
Talk to your doctor about early screening and treatment options.
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Sign Up and Stay ConnectedImportant Safety Information and Approved Use
What is the most important information I should know about TZIELD? TZIELD may cause serious side effects. These include:- Cytokine release syndrome (CRS). Signs and symptoms may start during the first 5 days of TZIELD treatment and could include fever, nausea, feeling tired (fatigue), headache, muscle and joint pain, or increased liver enzymes in your blood. Tell your healthcare provider right away if you develop any signs and symptoms of CRS during treatment with TZIELD
- Decrease in white blood cells. TZIELD may cause a decrease in a type of white blood cell called lymphocytes. A decrease in white blood cells is a serious, but common side effect that can affect your body’s ability to fight infections. A decrease in white blood cell counts can happen after your first dose. Your white blood cell counts will start to go back to normal after your fifth dose of TZIELD. Some people may develop longer and more severe decreases in lymphocytes
Your healthcare provider will do blood tests to check your liver and your complete blood counts before you start treatment and during treatment with TZIELD. During and after your treatment with TZIELD, your healthcare provider will check for serious side effects, as well as other side effects, and treat you as needed. Your healthcare provider may temporarily or completely stop your treatment with TZIELD, if you develop liver problems, have a serious infection, or if your blood counts stay too low.
What should I tell my healthcare provider before receiving TZIELD? Before or after receiving TZIELD, tell your healthcare provider about all your medical conditions, including if you:- have a serious infection or an infection that does not go away or keeps coming back
- have recently received or are scheduled to receive an immunization (vaccine). TZIELD may affect how well a vaccine works. Tell your doctor that you are receiving TZIELD before receiving a vaccine
- are pregnant or plan to become pregnant. TZIELD may harm your unborn baby. Do not receive TZIELD during pregnancy and at least 30 days before a planned pregnancy
- are breastfeeding or plan to breastfeed. It is not known if TZIELD passes into your breast milk and if it can harm your baby. Talk to your healthcare provider about the best way to feed your baby if you receive TZIELD
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
What are the possible side effects of TZIELD? The most common side effects of TZIELD include:- rash
- leukopenia (decrease in white blood cell counts)
- headache
These are not all of the possible side effects of TZIELD. Talk to your healthcare provider for more information, and tell them about any side effects you notice. You may report side effects to the FDA at www.fda.gov/medwatch or 1-800-FDA-1088.
Please see Medication Guide and Prescribing Information.
What is TZIELD?
TZIELD is a prescription medicine used to delay the onset of Stage 3 type 1 diabetes, which is when your body can’t make enough insulin on its own and may require insulin injections. TZIELD is for adults and children 8 years of age and older who have Stage 2 type 1 diabetes. This means that they have tested positive for 2 or more type 1 diabetes-related autoantibodies, have abnormal blood sugar levels, and do not have type 2 diabetes.
It is not known if TZIELD is safe and effective in children under 8 years of age.
Important Safety Information and Approved Use
- Cytokine release syndrome (CRS). Signs and symptoms may start during the first 5 days of TZIELD treatment and could include fever, nausea, feeling tired (fatigue), headache, muscle and joint pain, or increased liver enzymes in your blood. Tell your healthcare provider right away if you develop any signs and symptoms of CRS during treatment with TZIELD
- Decrease in white blood cells. TZIELD may cause a decrease in a type of white blood cell called lymphocytes. A decrease in white blood cells is a serious, but common side effect that can affect your body’s ability to fight infections. A decrease in white blood cell counts can happen after your first dose. Your white blood cell counts will start to go back to normal after your fifth dose of TZIELD. Some people may develop longer and more severe decreases in lymphocytes
Your healthcare provider will do blood tests to check your liver and your complete blood counts before you start treatment and during treatment with TZIELD. During and after your treatment with TZIELD, your healthcare provider will check for serious side effects, as well as other side effects, and treat you as needed. Your healthcare provider may temporarily or completely stop your treatment with TZIELD, if you develop liver problems, have a serious infection, or if your blood counts stay too low.
What should I tell my healthcare provider before receiving TZIELD? Before or after receiving TZIELD, tell your healthcare provider about all your medical conditions, including if you:- have a serious infection or an infection that does not go away or keeps coming back
- have recently received or are scheduled to receive an immunization (vaccine). TZIELD may affect how well a vaccine works. Tell your doctor that you are receiving TZIELD before receiving a vaccine
- are pregnant or plan to become pregnant. TZIELD may harm your unborn baby. Do not receive TZIELD during pregnancy and at least 30 days before a planned pregnancy
- are breastfeeding or plan to breastfeed. It is not known if TZIELD passes into your breast milk and if it can harm your baby. Talk to your healthcare provider about the best way to feed your baby if you receive TZIELD
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
What are the possible side effects of TZIELD? The most common side effects of TZIELD include:- rash
- leukopenia (decrease in white blood cell counts)
- headache
These are not all of the possible side effects of TZIELD. Talk to your healthcare provider for more information, and tell them about any side effects you notice. You may report side effects to the FDA at www.fda.gov/medwatch or 1-800-FDA-1088.
Please see Medication Guide and Prescribing Information.
What is TZIELD?
TZIELD is a prescription medicine used to delay the onset of Stage 3 type 1 diabetes, which is when your body can’t make enough insulin on its own and may require insulin injections. TZIELD is for adults and children 8 years of age and older who have Stage 2 type 1 diabetes. This means that they have tested positive for 2 or more type 1 diabetes-related autoantibodies, have abnormal blood sugar levels, and do not have type 2 diabetes.
It is not known if TZIELD is safe and effective in children under 8 years of age.