About screening

The sooner you screen for type 1 diabetes (T1D), the earlier you can learn what steps to take next

A father and son smiling outdoors and the son is holding a basketball

Actor portrayal

Understanding who is really at risk for T1D

A person

Anyone at any age can develop T1D, although some are at higher risk

Up to 15 times higher

Up to 15x higher risk if you have a family history of T1D

Up to 3 times higher

Up to 3x higher risk if you have certain autoimmune diseases, including Graves’, Hashimoto’s, and celiac disease

The ADA (American Diabetes Association) recommends that people with a family history of T1D or elevated genetic risk be screened for the following T1D-related autoantibodies: GADA, IA-2A, IAA, and ZnT8A.

ICA is another autoantibody that is available for testing.

A droplet
Do you have a history of prediabetes or abnormal blood sugar?

Abnormal blood sugar is a symptom that appears in both T1D and type 2 diabetes. Screening for T1D can help ensure the right diagnosis and treatment plan.

Why is it so important to screen early?

Talking to your doctor about screening for T1D with an autoantibody (AAb) test is a proactive way to take charge of your or your loved one's health. The time to screen is now.

AAb screening can help detect T1D before symptoms appear

In fact, AAb screening has been found to help reduce the risk of a T1D-related medical emergency at diagnosis by up to 50%. Just as routine mammograms and colonoscopies are powerful tools for early detection of disease, proactive AAb screening is another important step you can take to help protect your health.

Acting early gives you valuable knowledge and time

Although there is currently no way to prevent T1D from developing, knowing early can give you more time to learn about and prepare for T1D without the stress and anxiety of being diagnosed in an emergency situation.

A scale with the meter pointing to the far right

T1D progresses rapidly in young children

This makes timely screening of at-risk children especially important. A positive test could lead to an opportunity to treat T1D in Stage 2 before it progresses to Stage 3 and requires daily insulin management.

Transcript

TZIELD indication card

Amanda VO:
“We are being compensated by Sanofi to share our story.”

Amanda, TZIELD caregiver
[Compensated by Sanofi]

“In 2020, we noticed that our daughter Jenna had become increasingly lethargic. Sleeping late, going to bed early, napping. She had also been extremely thirsty.

We kept digging on our own and discovered that Type 1 Diabetes was a possibility for her. So, we did purchase a glucometer. We tested her blood sugar, and she was 565.”

“So, we went to the emergency room, where she was admitted to the ICU and that started our journey with Type 1 Diabetes.

I learned that you are up to 15 times more likely to have type 1 Diabetes if you have a direct family relative, and that was very concerning to us.”

“We learned that our son tested positive for multiple autoantibodies. We also learned that he had abnormal blood glucose levels which indicated positivity for Stage 2 of Type 1 Diabetes. To me, there is absolutely no disadvantage to knowing. Knowledge is power.”

See Amanda’s full story on the Real Talk About Type 1 & TZIELD page

[TZIELD logo]

What is TZIELD?
TZIELD is a prescription medicine used to delay the onset of Stage 3 type 1 diabetes, which is when your body can’t make enough insulin on its own and may require insulin injections. TZIELD is for adults and children 8 years of age and older who have Stage 2 type 1 diabetes. This means that they have tested positive for 2 or more type 1 diabetes-related autoantibodies, have abnormal blood sugar levels, and do not have type 2 diabetes.

It is not known if TZIELD is safe and effective in children under 8 years of age.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about TZIELD?

TZIELD may cause serious side effects. These include:

  • Cytokine release syndrome (CRS). Signs and symptoms may start during the first 5 days of TZIELD treatment and could include fever, nausea, feeling tired (fatigue), headache, muscle and joint pain, or increased liver enzymes in your blood. Tell your healthcare provider right away if you develop any signs and symptoms of CRS during treatment with TZIELD
  • Decrease in white blood cells. TZIELD may cause a decrease in a type of white blood cell called lymphocytes. A decrease in white blood cells is a serious, but common side effect that can affect your body’s ability to fight infections. A decrease in white blood cell counts can happen after your first dose. Your white blood cell counts will start to go back to normal after your fifth dose of TZIELD. Some people may develop longer and more severe decreases in lymphocytes

Your healthcare provider will do blood tests to check your liver and your complete blood counts before you start treatment and during treatment with TZIELD. During and after your treatment with TZIELD, your healthcare provider will check for serious side effects, as well as other side effects, and treat you as needed. Your healthcare provider may temporarily or completely stop your treatment with TZIELD, if you develop liver problems, have a serious infection, or if your blood counts stay too low.

What should I tell my healthcare provider before receiving TZIELD?

Before or after receiving TZIELD, tell your healthcare provider about all your medical conditions, including if you:

  • have a serious infection or an infection that does not go away or keeps coming back
  • have recently received or are scheduled to receive an immunization (vaccine). TZIELD may affect how well a vaccine works. Tell your doctor that you are receiving TZIELD before receiving a vaccine
  • are pregnant or plan to become pregnant. TZIELD may harm your unborn baby. Do not receive TZIELD during pregnancy and at least 30 days before a planned pregnancy
  • are breastfeeding or plan to breastfeed. It is not known if TZIELD passes into your breast milk and if it can harm your baby. Talk to your healthcare provider about the best way to feed your baby if you receive TZIELD

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of TZIELD?

The most common side effects of TZIELD include:

  • rash
  • leukopenia (decrease in white blood cell counts)
  • headache

These are not all of the possible side effects of TZIELD. Talk to your healthcare provider for more information, and tell them about any side effects you notice. You may report side effects to the FDA at www.fda.gov/medwatch or 1-800-FDA-1088.

Please see [accompanying] Medication Guide and Prescribing Information.

MAT-US-2407582-v1.0-09/2024

Watch real stories from real people

Hear from 3 people who were caught off guard by their T1D diagnosis, and how it inspired them to educate others on the importance of early screening.

More T1D Diagnosis Stories

Amanda and John are Ambassadors sponsored by Sanofi.

What is the screening process for T1D?

A warning exclamation point

What you should know before you screen

A doctor

There are many ways to screen for T1D

Your doctor can help you determine where and how you should get screened.

A droplet with a checkmark over it

AAb screening is different than a blood sugar test or a genetic test

It must be requested separately from annual bloodwork.

A dollar sign with a down arrow on it

Screening is often low or sometimes no cost, depending on insurance and where you screen

8 out of 10 commercially insured patients pay less than $20* for AAb screening.

*n=2114. Analysis has been conducted using LAAD Medical and Remittance data from May 2023 to April 2024. Includes commercial claims with one of the following current procedural technology (CPT) codes: 86341 and/or 86337. Note: The analysis does not differentiate between the number of AAbs tested within each claim.

A locator pin

Where to get screened

1. Doctor’s Office or Lab†

You can get screened at a doctor’s office or at a lab like Labcorp or Quest Diagnostics.

Type of test: Blood draw

Cost: Most insurance plans cover some or all of the cost

Doctor Discussion Guide

2. ASK‡

All US residents can order at-home screening kits online. Residents of Colorado can also get kits at certain screening locations.

Type of test: Blood draw or finger stick

Cost: Free for US residents aged 1 year and older with or without a family history of T1D

ASK Health

3. Quest Health

Get the same lab tests doctors use and recommend, and access your results online as soon as they’re available.

Type of test: Blood draw

Cost: $149 plus service fee

Questhealth.com

4. TrialNet§II

Screening can take place at TrialNet locations, events, or health fairs. You can also receive a screening kit to use at home or to bring in to a Labcorp or Quest Diagnostics location.

Type of test: Blood draw or finger stick

Cost: Free for people with a relative with T1D

TrialNet

These are not all the screening options available. It’s important to talk to your doctor about the best screening option for you. Inclusion on this list does not imply the endorsement of Sanofi.

†Selection of AAb assays are at the HCP’s sole discretion.

‡Autoimmunity Screening for Kids.

§TrialNet will initially test for 2 AAbs. If 1 or more AAbs are found in the first test, additional testing may be done for other AAbs as indicated by the grey check-marked boxes.

IIFor ages 2-45 years old with a first-degree relative and 2-20 years old with a second-degree relative.

A hand with a droplet on the index finger

What to expect during screening

A droplet

Complete a Blood Test

The blood test will either be a finger prick or a blood draw and can be done at a clinic or at home.

A test tube filled with liquid

Lab Analysis

Your blood will then be sent to a lab to check for T1D-related AAbs.

A magnifying glass with an eye in it

Await Results

While you are waiting for results to come back, remember that you’ve taken an important first step to manage your health.

A care team

Understanding the 3 AAb test results

Your doctor will explain what your results mean, whether more testing is needed, and potential next steps, including treatment options like TZIELD.

0

0 T1D AAbs found

What it means: Right now, there are no signs that your immune system is reacting in a way that’s linked to T1D, but it doesn't mean AAbs can't or won't develop over time.

What to do:

  • Talk to your doctor about getting rescreened if you have risk factors like:
    • A family history of T1D
    • An autoimmune disease like Graves’, Hashimoto’s, or celiac disease
1

1 T1D AAb found

What it means: One AAb is an early signal and means you may be at higher risk, but it doesn't mean you're guaranteed to develop T1D.

What to do:

  • The American Diabetes Association recommends getting your blood sugar tested to make sure insulin-dependent (Stage 3) T1D hasn't already developed.
  • If your blood sugar levels are still within a healthy range, talk with your doctor about an appropriate rescreening schedule
2 or more

2+ T1D AAbs found

What it means: If 2 or more AAbs are found and you do not yet have very high blood sugar, you're in early-stage T1D (Stage 1 or Stage 2) and have a high risk of progression to insulin-dependent (Stage 3) T1D. Understandably, this may come as a surprise, but rest assured, you aren’t alone—your doctor is there to help you navigate your next steps.

What to do:

  • Work with your doctor on next steps, including following up with an endocrinologist who may recommend additional testing, education, and management options

Receiving this kind of news can be uncertain or scary, but you’re not alone. There are resources and support available for you and your family.

Have you gotten your screening results?

Get help starting a conversation with your doctor about what they mean and next steps.

Doctor Discussion GuideAAb Results Explainer

Find a T1D specialist near you

T1D specialists are also called endocrinologists. They can diagnose, treat, and manage type 1 diabetes for you or your loved one.

Start Your Search

The search tool and results are provided independently by Healthgrades™. Sanofi does not endorse or recommend any particular physician and search results may not include a comprehensive list of doctors in your area. Sanofi is not responsible for any Healthgrades content.

An opportunity to reshape the journey ahead

The first step is screening. If you test positive for 2 or more T1D-related autoantibodies and have abnormal blood sugar levels, a next step could be TZIELD.

How TZIELD can help
A teacher smiling at her student working at their desk

Actor portrayal

Important Safety Information and Indication

What is the most important information I should know about TZIELD? TZIELD may cause serious side effects. These including:
  • Viral Reactivation. Epstein-Barr virus (EBV) and cytomegalovirus (CMV) are common viruses that may stay inactive in your body after an initial infection. TZIELD may cause these viruses to become active again which, especially in patients with a weakened immune system, can become serious and potentially life-threatening. These viral reactivations can happen during treatment with TZIELD and up to 2 months after your last dose. Your healthcare provider will test you for active EBV and CMV infections before treatment with TZIELD. Contact your healthcare provider right away if you develop symptoms of an infection during or after treatment with TZIELD (such as fever, swollen glands, or fatigue).
  • Cytokine release syndrome (CRS). Signs and symptoms may start during the first 5 days of TZIELD treatment and could include fever, nausea (with or without vomiting), feeling tired (fatigue), headache, muscle and joint pain, or increased liver enzymes in your blood. Tell your healthcare provider right away if you develop any signs and symptoms of CRS during treatment with TZIELD. 
  • Decrease in white blood cells. TZIELD may cause a decrease in a type of white blood cell called lymphocytes. A decrease in white blood cells is a serious, but common side effect that can affect your body’s ability to fight infections. A decrease in white blood cell counts can happen after your first dose. Your white blood cell counts will start to go back to normal after your fifth dose of TZIELD. Some people may develop longer and more severe decreases in lymphocytes.

Your healthcare provider will do blood tests to check for active infections, verify your liver function and your complete blood counts before you start treatment and during treatment with TZIELD. During and after your treatment with TZIELD, your healthcare provider will check for serious side effects, as well as other side effects, and treat you as needed. Your healthcare provider may temporarily or completely stop your treatment with TZIELD, if you develop liver problems, have a serious infection or viral reactivation, or if your blood counts stay too low.  

What should I tell my healthcare provider before receiving TZIELD? Before or after receiving TZIELD, tell your healthcare provider about all your medical conditions, including if you:
  • have any of the conditions or symptoms listed in the section “What is the most important information I should know about TZIELD?”
  • have a weakened immune system, including if you have Down syndrome.
  • have a serious infection or an infection that does not go away or keeps coming back (chronic). 
  • have recently received or are scheduled to receive an immunization (vaccine). TZIELD may affect how well a vaccine works. Tell your healthcare provider that you are receiving treatment with TZIELD before receiving a vaccine.
  • are pregnant or plan to become pregnant. TZIELD may harm your unborn baby.  Do not receive TZIELD during pregnancy and at least 30 days before a planned pregnancy.  

If you become pregnant while taking TZIELD, you are encouraged to report your pregnancy to us at our Adverse Event reporting line at 1-800-633-1610 or visit https://ae.reporting.sanofi.

  • are breastfeeding or plan to breastfeed. It is not known if TZIELD passes into your breast milk and if it can harm your baby. Talk to your healthcare provider about the best way to feed your baby if you receive TZIELD.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of TZIELD? The most common side effects of TZIELD include:
  • decrease in white blood cell counts
  • vomiting
  • rash
  • diarrhea
  • headache

These are not all of the possible side effects of TZIELD. For more information, ask your healthcare provider or pharmacist. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects to us at 1-800-633-1610 or www.fda.gov/medwatch or 1-800-FDA-1088.

Please see full Prescribing Information, including Risk of SERIOUS SIDE EFFECTS and Medication Guide.

What is TZIELD?

TZIELD is a prescription medicine used to delay the onset of Stage 3 type 1 diabetes, which is when your body cannot make enough insulin on its own and may require insulin injections. TZIELD is for adults and children 1 year of age and older who have Stage 2 type 1 diabetes. This means that they have tested positive for 2 or more type 1 diabetes-related autoantibodies, have abnormal blood sugar levels, and do not have type 2 diabetes or other forms of diabetes.

It is not known if TZIELD is safe and effective in children under 1 years of age.

Important Safety Information and Indication

What is the most important information I should know about TZIELD? TZIELD may cause serious side effects. These including:
  • Viral Reactivation. Epstein-Barr virus (EBV) and cytomegalovirus (CMV) are common viruses that may stay inactive in your body after an initial infection. TZIELD may cause these viruses to become active again which, especially in patients with a weakened immune system, can become serious and potentially life-threatening. These viral reactivations can happen during treatment with TZIELD and up to 2 months after your last dose. Your healthcare provider will test you for active EBV and CMV infections before treatment with TZIELD. Contact your healthcare provider right away if you develop symptoms of an infection during or after treatment with TZIELD (such as fever, swollen glands, or fatigue).
  • Cytokine release syndrome (CRS). Signs and symptoms may start during the first 5 days of TZIELD treatment and could include fever, nausea (with or without vomiting), feeling tired (fatigue), headache, muscle and joint pain, or increased liver enzymes in your blood. Tell your healthcare provider right away if you develop any signs and symptoms of CRS during treatment with TZIELD. 
  • Decrease in white blood cells. TZIELD may cause a decrease in a type of white blood cell called lymphocytes. A decrease in white blood cells is a serious, but common side effect that can affect your body’s ability to fight infections. A decrease in white blood cell counts can happen after your first dose. Your white blood cell counts will start to go back to normal after your fifth dose of TZIELD. Some people may develop longer and more severe decreases in lymphocytes.

Your healthcare provider will do blood tests to check for active infections, verify your liver function and your complete blood counts before you start treatment and during treatment with TZIELD. During and after your treatment with TZIELD, your healthcare provider will check for serious side effects, as well as other side effects, and treat you as needed. Your healthcare provider may temporarily or completely stop your treatment with TZIELD, if you develop liver problems, have a serious infection or viral reactivation, or if your blood counts stay too low.  

What should I tell my healthcare provider before receiving TZIELD? Before or after receiving TZIELD, tell your healthcare provider about all your medical conditions, including if you:
  • have any of the conditions or symptoms listed in the section “What is the most important information I should know about TZIELD?”
  • have a weakened immune system, including if you have Down syndrome.
  • have a serious infection or an infection that does not go away or keeps coming back (chronic). 
  • have recently received or are scheduled to receive an immunization (vaccine). TZIELD may affect how well a vaccine works. Tell your healthcare provider that you are receiving treatment with TZIELD before receiving a vaccine.
  • are pregnant or plan to become pregnant. TZIELD may harm your unborn baby.  Do not receive TZIELD during pregnancy and at least 30 days before a planned pregnancy.  

If you become pregnant while taking TZIELD, you are encouraged to report your pregnancy to us at our Adverse Event reporting line at 1-800-633-1610 or visit https://ae.reporting.sanofi.

  • are breastfeeding or plan to breastfeed. It is not known if TZIELD passes into your breast milk and if it can harm your baby. Talk to your healthcare provider about the best way to feed your baby if you receive TZIELD.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of TZIELD? The most common side effects of TZIELD include:
  • decrease in white blood cell counts
  • vomiting
  • rash
  • diarrhea
  • headache

These are not all of the possible side effects of TZIELD. For more information, ask your healthcare provider or pharmacist. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects to us at 1-800-633-1610 or www.fda.gov/medwatch or 1-800-FDA-1088.

Please see full Prescribing Information, including Risk of SERIOUS SIDE EFFECTS and Medication Guide.

What is TZIELD?

TZIELD is a prescription medicine used to delay the onset of Stage 3 type 1 diabetes, which is when your body cannot make enough insulin on its own and may require insulin injections. TZIELD is for adults and children 1 year of age and older who have Stage 2 type 1 diabetes. This means that they have tested positive for 2 or more type 1 diabetes-related autoantibodies, have abnormal blood sugar levels, and do not have type 2 diabetes or other forms of diabetes.

It is not known if TZIELD is safe and effective in children under 1 years of age.