About screening
The sooner you screen for T1D, the earlier you can learn what steps to take next
Understanding who is really at risk for T1D
Anyone at any age can develop T1D, although some are at higher risk
Up to 15x higher risk if you have a family history of T1D
Up to 3x higher risk if you have certain autoimmune diseases, including Graves’, Hashimoto’s, and celiac disease
The ADA (American Diabetes Association) recommends that people with a family history of T1D or certain autoimmune diseases be screened for the following T1D-related autoantibodies: GADA, IA-2A,IAA, and ZnT8A.
ICA is another autoantibody that is available for testing.
Do you have a history of pre-diabetes or abnormal blood sugar?
Abnormal blood sugar is a symptom that appears in both T1D and type 2 diabetes. Screening for T1D can help ensure the right diagnosis and treatment plan.
Why is it so important to screen early?
Talking to your doctor about screening for T1D with an autoantibody (AAb) test is a powerful way to take charge of your or your loved one's health. The time to screen is now.
AAb screening can help detect T1D before symptoms appear
In fact, AAb screening has been found to help reduce the risk of a potential medical emergency associated with T1D by up to 50%. Just as routine mammograms and colonoscopies are powerful tools for early detection of disease, proactive AAb screening is another important step you can take to help protect your health.
Acting early gives you valuable knowledge and time
Although there is currently no way to prevent T1D from developing, knowing early can give you more time to learn about and prepare for T1D without the stress and anxiety of being diagnosed in an emergency situation.
What is the screening process for T1D?
What you should know before you screen
There are many ways to screen for T1D
Your doctor can help you determine where and how you should get screened.
AAb screening is different than a blood sugar test or a genetic test
It must be requested separately from annual bloodwork.
Screening is often low or sometimes no cost, depending on insurance and where you screen
8 out of 10 commercially insured patients pay less than $20* for AAb screening.
*n=2114. Analysis has been conducted using LAAD Medical and Remittance data from May 2023 to April 2024. Includes commercial claims with one of the following current procedural technology (CPT) codes: 86341 and/or 86337. Note: The analysis does not differentiate between the number of AAbs tested within each claim.
Where to get screened
1. Doctor’s Office or Lab*
You can get screened at a doctor’s office or at a lab like Labcorp® or Quest Diagnostics®.
Type of test: Blood draw
Cost: Most insurance plans cover some or all of the cost
2. T1D Screening Central*
US residents can make a telehealth appointment, get a screening order for a lab or request a home kit.
Type of test: Blood draw or finger stick
Cost: Costs are variable based on services
3. ASK†
All US residents can order at-home screening kits online. Residents of Colorado can also get kits at certain screening locations.
Type of test: Blood draw or finger stick
Cost: Free for US residents aged 1 year and older with or without a family history of T1D
4. Quest Health
Get the same lab tests doctors use and recommend, and access your results online as soon as they’re available.
Type of test: Blood draw
Cost: $149 plus service fee
5. TrialNet‡§
Screening can take place at TrialNet locations, events, or health fairs. You can also receive a screening kit to use at home or to bring in to a Labcorp® or Quest Diagnostics® location.
Type of test: Blood draw or finger stick
Cost: Free for people with a first-degree relative with T1D
These are not all the screening options available. It’s important to talk to your doctor about the best screening option for you. Inclusion on this list does not imply the endorsement of Sanofi.
*Selection of AAb assays are at the HCP’s sole discretion.
†Autoimmunity Screening for Kids.
‡TrialNet will initially test for 2 AAbs. If 1 or more AAbs are found in the first test, additional testing may be done for other AAbs as indicated by the grey check-marked boxes.
§For ages 2–45 years old with a first-degree relative and 2–20 years old with a second-degree relative.
What to expect during screening
Simple Blood Test
The blood test will either be a finger prick or a blood draw and can be done at a clinic or at home.
Lab Analysis
Your blood will then be sent to a lab to check for T1D-related AAbs.
Await Results
While you are waiting for results to come back, remember that you’ve taken an important first step to manage your health.
Understanding the 3 AAb test results
Your doctor will explain what your results mean, whether more testing is needed, and potential next steps, including treatment options like TZIELD.
0 T1D AAbs found
What it means: Right now, there are no signs that your immune system is reacting in a way that’s linked to T1D, but it doesn't mean AAbs can't or won't develop over time.
What to do:
- Talk to your doctor about getting rescreened if you have risk factors like:
- A family history of T1D
- An autoimmune disease like Graves’, Hashimoto’s, or celiac disease
1 T1D AAb found
What it means: One AAb is an early signal, but it doesn't mean you're guaranteed to develop T1D.
What to do:
- Talk to your doctor about a rescreening schedule to monitor for additional AAbs
2+ T1D AAbs found
What it means: This result could indicate early-stage T1D may have begun, meaning the disease is already developing in your body even if you feel fine or don't have any visible symptoms.
What to do:
- Work with your doctor on next steps, including following up with an endocrinologist who may recommend additional testing
Receiving this kind of news can be uncertain or scary, but you’re not alone. There are resources and support available for you and your family.
Have you gotten your screening results?
Get help starting a conversation with your doctor about what they mean and next steps.
WH:EN is an opportunity to reshape the journey ahead
The first step is screening. If you test positive for 2 or more T1D-related autoantibodies and have abnormal blood sugar levels, a next step could be TZIELD.
How TZIELD can help
Important Safety Information and Approved Use
What is the most important information I should know about TZIELD? TZIELD may cause serious side effects. These include:- Cytokine release syndrome (CRS). Signs and symptoms may start during the first 5 days of TZIELD treatment and could include fever, nausea, feeling tired (fatigue), headache, muscle and joint pain, or increased liver enzymes in your blood. Tell your healthcare provider right away if you develop any signs and symptoms of CRS during treatment with TZIELD
- Decrease in white blood cells. TZIELD may cause a decrease in a type of white blood cell called lymphocytes. A decrease in white blood cells is a serious, but common side effect that can affect your body’s ability to fight infections. A decrease in white blood cell counts can happen after your first dose. Your white blood cell counts will start to go back to normal after your fifth dose of TZIELD. Some people may develop longer and more severe decreases in lymphocytes
Your healthcare provider will do blood tests to check your liver and your complete blood counts before you start treatment and during treatment with TZIELD. During and after your treatment with TZIELD, your healthcare provider will check for serious side effects, as well as other side effects, and treat you as needed. Your healthcare provider may temporarily or completely stop your treatment with TZIELD, if you develop liver problems, have a serious infection, or if your blood counts stay too low.
What should I tell my healthcare provider before receiving TZIELD? Before or after receiving TZIELD, tell your healthcare provider about all your medical conditions, including if you:- have a serious infection or an infection that does not go away or keeps coming back
- have recently received or are scheduled to receive an immunization (vaccine). TZIELD may affect how well a vaccine works. Tell your doctor that you are receiving TZIELD before receiving a vaccine
- are pregnant or plan to become pregnant. TZIELD may harm your unborn baby. Do not receive TZIELD during pregnancy and at least 30 days before a planned pregnancy
- are breastfeeding or plan to breastfeed. It is not known if TZIELD passes into your breast milk and if it can harm your baby. Talk to your healthcare provider about the best way to feed your baby if you receive TZIELD
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
What are the possible side effects of TZIELD? The most common side effects of TZIELD include:- rash
- leukopenia (decrease in white blood cell counts)
- headache
These are not all of the possible side effects of TZIELD. Talk to your healthcare provider for more information, and tell them about any side effects you notice. You may report side effects to the FDA at www.fda.gov/medwatch or 1-800-FDA-1088.
Please see Medication Guide and Prescribing Information.
What is TZIELD?
TZIELD is a prescription medicine used to delay the onset of Stage 3 type 1 diabetes, which is when your body can’t make enough insulin on its own and may require insulin injections. TZIELD is for adults and children 8 years of age and older who have Stage 2 type 1 diabetes. This means that they have tested positive for 2 or more type 1 diabetes-related autoantibodies, have abnormal blood sugar levels, and do not have type 2 diabetes.
It is not known if TZIELD is safe and effective in children under 8 years of age.
Important Safety Information and Approved Use
- Cytokine release syndrome (CRS). Signs and symptoms may start during the first 5 days of TZIELD treatment and could include fever, nausea, feeling tired (fatigue), headache, muscle and joint pain, or increased liver enzymes in your blood. Tell your healthcare provider right away if you develop any signs and symptoms of CRS during treatment with TZIELD
- Decrease in white blood cells. TZIELD may cause a decrease in a type of white blood cell called lymphocytes. A decrease in white blood cells is a serious, but common side effect that can affect your body’s ability to fight infections. A decrease in white blood cell counts can happen after your first dose. Your white blood cell counts will start to go back to normal after your fifth dose of TZIELD. Some people may develop longer and more severe decreases in lymphocytes
Your healthcare provider will do blood tests to check your liver and your complete blood counts before you start treatment and during treatment with TZIELD. During and after your treatment with TZIELD, your healthcare provider will check for serious side effects, as well as other side effects, and treat you as needed. Your healthcare provider may temporarily or completely stop your treatment with TZIELD, if you develop liver problems, have a serious infection, or if your blood counts stay too low.
What should I tell my healthcare provider before receiving TZIELD? Before or after receiving TZIELD, tell your healthcare provider about all your medical conditions, including if you:- have a serious infection or an infection that does not go away or keeps coming back
- have recently received or are scheduled to receive an immunization (vaccine). TZIELD may affect how well a vaccine works. Tell your doctor that you are receiving TZIELD before receiving a vaccine
- are pregnant or plan to become pregnant. TZIELD may harm your unborn baby. Do not receive TZIELD during pregnancy and at least 30 days before a planned pregnancy
- are breastfeeding or plan to breastfeed. It is not known if TZIELD passes into your breast milk and if it can harm your baby. Talk to your healthcare provider about the best way to feed your baby if you receive TZIELD
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
What are the possible side effects of TZIELD? The most common side effects of TZIELD include:- rash
- leukopenia (decrease in white blood cell counts)
- headache
These are not all of the possible side effects of TZIELD. Talk to your healthcare provider for more information, and tell them about any side effects you notice. You may report side effects to the FDA at www.fda.gov/medwatch or 1-800-FDA-1088.
Please see Medication Guide and Prescribing Information.
What is TZIELD?
TZIELD is a prescription medicine used to delay the onset of Stage 3 type 1 diabetes, which is when your body can’t make enough insulin on its own and may require insulin injections. TZIELD is for adults and children 8 years of age and older who have Stage 2 type 1 diabetes. This means that they have tested positive for 2 or more type 1 diabetes-related autoantibodies, have abnormal blood sugar levels, and do not have type 2 diabetes.
It is not known if TZIELD is safe and effective in children under 8 years of age.