Anyone at any age can develop T1D, although some are at higher risk
Up to 15x higher risk if you have a family history of T1D
Up to 3x higher risk if you have certain autoimmune diseases, including Graves’, Hashimoto’s, and celiac disease
The ADA (American Diabetes Association) recommends that people with a family history of T1D or elevated genetic risk be screened for the following T1D-related autoantibodies: GADA, IA-2A, IAA, and ZnT8A.
ICA is another autoantibody that is available for testing.
Abnormal blood sugar is a symptom that appears in both T1D and type 2 diabetes. Screening for T1D can help ensure the right diagnosis and treatment plan.
Talking to your doctor about screening for T1D with an autoantibody (AAb) test is a proactive way to take charge of your or your loved one's health. The time to screen is now.
In fact, AAb screening has been found to help reduce the risk of a T1D-related medical emergency at diagnosis by up to 50%. Just as routine mammograms and colonoscopies are powerful tools for early detection of disease, proactive AAb screening is another important step you can take to help protect your health.
Although there is currently no way to prevent T1D from developing, knowing early can give you more time to learn about and prepare for T1D without the stress and anxiety of being diagnosed in an emergency situation.
This makes timely screening of at-risk children especially important. A positive test could lead to an opportunity to treat T1D in Stage 2 before it progresses to Stage 3 and requires daily insulin management.
Your doctor can help you determine where and how you should get screened.
It must be requested separately from annual bloodwork.
8 out of 10 commercially insured patients pay less than $20* for AAb screening.
*n=2114. Analysis has been conducted using LAAD Medical and Remittance data from May 2023 to April 2024. Includes commercial claims with one of the following current procedural technology (CPT) codes: 86341 and/or 86337. Note: The analysis does not differentiate between the number of AAbs tested within each claim.
You can get screened at a doctor’s office or at a lab like Labcorp or Quest Diagnostics.
Type of test: Blood draw
Cost: Most insurance plans cover some or all of the cost
All US residents can order at-home screening kits online. Residents of Colorado can also get kits at certain screening locations.
Type of test: Blood draw or finger stick
Cost: Free for US residents aged 1 year and older with or without a family history of T1D
Get the same lab tests doctors use and recommend, and access your results online as soon as they’re available.
Type of test: Blood draw
Cost: $149 plus service fee
Screening can take place at TrialNet locations, events, or health fairs. You can also receive a screening kit to use at home or to bring in to a Labcorp or Quest Diagnostics location.
Type of test: Blood draw or finger stick
Cost: Free for people with a relative with T1D
These are not all the screening options available. It’s important to talk to your doctor about the best screening option for you. Inclusion on this list does not imply the endorsement of Sanofi.
†Selection of AAb assays are at the HCP’s sole discretion.
‡Autoimmunity Screening for Kids.
§TrialNet will initially test for 2 AAbs. If 1 or more AAbs are found in the first test, additional testing may be done for other AAbs as indicated by the grey check-marked boxes.
IIFor ages 2-45 years old with a first-degree relative and 2-20 years old with a second-degree relative.
The blood test will either be a finger prick or a blood draw and can be done at a clinic or at home.
Your blood will then be sent to a lab to check for T1D-related AAbs.
While you are waiting for results to come back, remember that you’ve taken an important first step to manage your health.
Your doctor will explain what your results mean, whether more testing is needed, and potential next steps, including treatment options like TZIELD.
What it means: Right now, there are no signs that your immune system is reacting in a way that’s linked to T1D, but it doesn't mean AAbs can't or won't develop over time.
What to do:
What it means: One AAb is an early signal and means you may be at higher risk, but it doesn't mean you're guaranteed to develop T1D.
What to do:
What it means: If 2 or more AAbs are found and you do not yet have very high blood sugar, you're in early-stage T1D (Stage 1 or Stage 2) and have a high risk of progression to insulin-dependent (Stage 3) T1D. Understandably, this may come as a surprise, but rest assured, you aren’t alone—your doctor is there to help you navigate your next steps.
What to do:
Receiving this kind of news can be uncertain or scary, but you’re not alone. There are resources and support available for you and your family.
Get help starting a conversation with your doctor about what they mean and next steps.
T1D specialists are also called endocrinologists. They can diagnose, treat, and manage type 1 diabetes for you or your loved one.
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The first step is screening. If you test positive for 2 or more T1D-related autoantibodies and have abnormal blood sugar levels, a next step could be TZIELD.
How TZIELD can help
Your healthcare provider will do blood tests to check for active infections, verify your liver function and your complete blood counts before you start treatment and during treatment with TZIELD. During and after your treatment with TZIELD, your healthcare provider will check for serious side effects, as well as other side effects, and treat you as needed. Your healthcare provider may temporarily or completely stop your treatment with TZIELD, if you develop liver problems, have a serious infection or viral reactivation, or if your blood counts stay too low.
What should I tell my healthcare provider before receiving TZIELD? Before or after receiving TZIELD, tell your healthcare provider about all your medical conditions, including if you:If you become pregnant while taking TZIELD, you are encouraged to report your pregnancy to us at our Adverse Event reporting line at 1-800-633-1610 or visit https://ae.reporting.sanofi.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
What are the possible side effects of TZIELD? The most common side effects of TZIELD include:These are not all of the possible side effects of TZIELD. For more information, ask your healthcare provider or pharmacist. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects to us at 1-800-633-1610 or www.fda.gov/medwatch or 1-800-FDA-1088.
Please see full Prescribing Information, including Risk of SERIOUS SIDE EFFECTS and Medication Guide.
What is TZIELD?
TZIELD is a prescription medicine used to delay the onset of Stage 3 type 1 diabetes, which is when your body cannot make enough insulin on its own and may require insulin injections. TZIELD is for adults and children 1 year of age and older who have Stage 2 type 1 diabetes. This means that they have tested positive for 2 or more type 1 diabetes-related autoantibodies, have abnormal blood sugar levels, and do not have type 2 diabetes or other forms of diabetes.
It is not known if TZIELD is safe and effective in children under 1 years of age.
Your healthcare provider will do blood tests to check for active infections, verify your liver function and your complete blood counts before you start treatment and during treatment with TZIELD. During and after your treatment with TZIELD, your healthcare provider will check for serious side effects, as well as other side effects, and treat you as needed. Your healthcare provider may temporarily or completely stop your treatment with TZIELD, if you develop liver problems, have a serious infection or viral reactivation, or if your blood counts stay too low.
What should I tell my healthcare provider before receiving TZIELD? Before or after receiving TZIELD, tell your healthcare provider about all your medical conditions, including if you:If you become pregnant while taking TZIELD, you are encouraged to report your pregnancy to us at our Adverse Event reporting line at 1-800-633-1610 or visit https://ae.reporting.sanofi.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
What are the possible side effects of TZIELD? The most common side effects of TZIELD include:These are not all of the possible side effects of TZIELD. For more information, ask your healthcare provider or pharmacist. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects to us at 1-800-633-1610 or www.fda.gov/medwatch or 1-800-FDA-1088.
Please see full Prescribing Information, including Risk of SERIOUS SIDE EFFECTS and Medication Guide.
What is TZIELD?
TZIELD is a prescription medicine used to delay the onset of Stage 3 type 1 diabetes, which is when your body cannot make enough insulin on its own and may require insulin injections. TZIELD is for adults and children 1 year of age and older who have Stage 2 type 1 diabetes. This means that they have tested positive for 2 or more type 1 diabetes-related autoantibodies, have abnormal blood sugar levels, and do not have type 2 diabetes or other forms of diabetes.
It is not known if TZIELD is safe and effective in children under 1 years of age.