How TZIELD is given

Before infusion

Prep with your healthcare team:

• Talk with your doctor about which site of care option and infusion method is right for you or your loved one
• Discuss the timing of any recent or upcoming vaccinations with your doctor, as treatment with TZIELD may impact how well they work
• Confirm the dates, times, and locations of the infusions and discuss any additional questions you have

Connect with TZIELD COMPASS, which can:

• Help with infusion scheduling and coordinating travel logistics if needed
• Provide education and practical support for the infusion process
• Help connect you with a TZIELD Mentor if you're feeling nervous and want to talk to someone who's been through treatment

Discuss lab work and pre-infusion medications

• Your doctor will order testing for active viral infections (which can be life-threatening) of EBV and CMV before starting treatment
• Your doctor will order blood tests for you or your loved one to check. for active infections, verify your liver function and your complete blood counts
• If infusing at home, you may have to travel to a lab of your choice to complete lab work
• For the first 5 days of treatment, your healthcare provider will give medicines to be taken by mouth before starting the TZIELD infusion. These medicines include pain relievers (such as ibuprofen, naproxen or acetaminophen), an antihistamine, and possibly an anti-nausea medicine. These medicines may help reduce symptoms of CRS such as fever, headache, muscle and joint pain, or nausea, with or without vomiting. Vomiting and diarrhea may occur more frequently in children less than 8 years of age.

During infusion

Step 1

It's important to make sure you or your loved one are feeling well before beginning the infusion. A member of the healthcare team will check vitals, including temperature and blood pressure, and may also do a quick blood draw to check liver function and complete blood counts.

Step 2

The TZIELD dose is personalized based on height and weight and will gradually increase over the first 5 days to help the body adjust. The healthcare team will give you or your loved one oral medications before infusion to help reduce potential side effects. These could include certain types of pain relievers, antihistamines, and anti-nausea medication.

Step 3

Your healthcare team will then prepare the medicine and start the infusion. During treatment, they will check for serious side effects including signs of viral reactivation, as well as other side effects, and treat you as needed. Your healthcare team may temporarily or completely stop your treatment with TZIELD if you develop liver problems, have a serious infection, or if your blood counts stay too low.* Remember, if anything feels off or different to you or your loved one, let your healthcare team know—they're there to help.

Step 4

After the infusion is finished, the healthcare team will remove the IV or disconnect the midline or PICC line. You can expect a period of monitoring after the infusion to ensure there are no reactions, and then you'll be free to leave. You or your loved one should be able to continue the day, as advised by your doctor.

*For those who experience a decrease in white blood cell counts, levels typically begin to recover after the 5th day of treatment and return to pre-treatment levels within 2 weeks of completing infusions.

After infusion

Discuss with your doctor

• Your doctor will discuss the right post-treatment monitoring and care plan for you or your loved one including monitoring for signs and symptoms of viral reactivation after treatment for at least 2 months after the last infusion.
• Talk to your doctor or healthcare team about resuming activities post-treatment.
• Schedule regular check-ins with your doctor to keep track of your or your loved one's health over time.

Monitoring type 1 diabetes (T1D) going forward

It’s important to know and watch for early signs or symptoms of T1D (like increased thirst, frequent urination, or more tiredness than normal) and talk to your healthcare team about any changes you or your loved one experience.

Your doctor may recommend periodic lab tests or tools like glucose monitoring to help keep an eye on your or your loved one's blood sugar levels and to monitor for diabetic ketoacidosis (DKA), a medical emergency that happens when the body doesn’t have enough insulin, causing dangerous acids (called ketones) to build up in the blood.