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How is
TZIELD GIVEN?

If your doctor decides TZIELD is right for you, here's what you can expect.

Get information on treatment steps and tips for infusion days.

Download the What to Expect Guide

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Get information on treatment steps and tips for infusion days.

Download the What to Expect Guide

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TZIELD is an intravenous (IV) infusion

This means it’s given through a needle into a vein in your arm. The infusions are:

once a day every day

for 14 days in a row
Calendar icon with text: "14 days"

at least

30 minutes long
Clock icon with text: “About 30 minutes"

You will also need some extra time before and after each infusion.
This is so a nurse can prepare the infusion and monitor you or your child for a short period afterwards.

If you miss a scheduled infusion, your doctor will continue your treatment on the next scheduled day. You will not receive 2 infusions on the same day.

BEFORE

treatment

After you've been
prescribed TZIELD, enroll in

Your COMPASS Navigator will confirm your insurance coverage and provide information about financial assistance options that may be available. They can also help you find an infusion location so you can schedule treatment.

TALK TO YOUR DOCTOR ABOUT THE INFUSION LOCATION THAT'S BEST FOR YOU

Some infusion locations could include:
Stethoscope icon with text "at a doctor's office" Infusion bag icon with text "at an infusion center" House icon with text "at home with a nurse"
You can talk to your doctor about finding a 2-week period for infusions that works for your schedule. If you are enrolled in Provention Bio COMPASS, your COMPASS Navigator may also be able to help.

TALK TO YOUR DOCTOR ABOUT BLOOD TESTS

Glass vial and blood drop icon
Your doctor will do blood tests to check your liver and your complete blood counts before you start treatment and during treatment with TZIELD.

During the 14-day

infusion period
Day 1: Ready, Set, Go!
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Day 5: Other medication icons

Managing infusion reactions

For the first 5 days of treatment, your doctor will give you medicines to take before the infusion. These could include certain types of painkillers, antihistamines, and anti-nausea remedies. They may help reduce any fever, headache, muscle/joint pain, or nausea that may be caused by a possible side effect of TZIELD.

Take note of how you're feeling

TZIELD may cause serious side effects. During and after treatment with TZIELD, your doctor will check for serious side effects, as well as other side effects. They may treat you for these or decide to stop treatment if you develop liver problems, have a serious infection, or if your blood counts stay too low.

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Day 7: Halfway through!

TALK TO YOUR DOCTOR

If you miss any infusion days, you may need to continue the next day to complete all 14 infusions.

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Day 12: You're almost there!
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Day 14

treatment is complete!

It’s time to celebrate and recognize this accomplishment!

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Follow up with your doctor

Your doctor may check in about any side effects or medical conditions after treatment. They can also help you work out the right schedule for checking your blood sugar levels and for follow-up appointments.

IMPORTANT SAFETY INFORMATION AND APPROVED USE

What is the most important information I should know about TZIELD?

TZIELD may cause serious side effects, including:

  • Cytokine Release Syndrome (CRS). Signs and symptoms of CRS problems may include:
    • fever
    • feeling tired (fatigue)
    • muscle and joint pain
    • nausea
    • headache
    • increased liver enzymes in your blood

      These signs and symptoms may start during the first 5 days of TZIELD treatment. Tell your healthcare provider right away if you develop any signs and symptoms of CRS during treatment with TZIELD.
  • Decrease in white blood cells. TZIELD may cause a decrease in a type of white blood cell called lymphocytes. A decrease in white blood cells is a serious, but common side effect that can affect your body's ability to fight infections.

Before or after receiving TZIELD, tell your healthcare provider about all your medical conditions, including if you:

  • have a serious infection or an infection that does not go away or that keeps coming back.
  • have recently received or are scheduled to receive an immunization (vaccine). TZIELD may affect how well a vaccine works. Tell your healthcare provider that you are receiving treatment with TZIELD before receiving a vaccine.
  • are pregnant or plan to become pregnant. TZIELD may harm your unborn baby. Do not receive TZIELD during pregnancy and at least 30 days before a planned pregnancy.
  • are breastfeeding or plan to breast feed. It is not known if TZIELD passes into your breast milk and if it can harm your baby. Talk to your healthcare provider about the best way to feed your baby if you receive TZIELD. If you are breastfeeding, you may consider pumping and throwing away your breast milk during treatment with TZIELD and for 20 days after receiving TZIELD treatment.

What are the possible side effects of TZIELD?

The most common side effects of TZIELD include:

  • rash
  • leukopenia (decrease in white blood cell counts)
  • headache

What is TZIELD?

TZIELD is a prescription medicine used to delay the onset of Stage 3 type 1 diabetes, which is when your body can't make enough insulin on its own and may require insulin injections. TZIELD is for adults and children 8 years of age and older who have Stage 2 type 1 diabetes. This means they have tested positive for 2 or more type 1 diabetes-related autoantibodies, have abnormal blood sugar levels, and do not have type 2 diabetes. It is not known if TZIELD is safe and effective in children under 8 years of age.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about TZIELD?

TZIELD may cause serious side effects, including:

  • Cytokine Release Syndrome (CRS). Signs and symptoms of CRS problems may include:
    • fever
    • feeling tired (fatigue)
    • muscle and joint pain
    • nausea
    • headache
    • increased liver enzymes in your blood

      These signs and symptoms may start during the first 5 days of TZIELD treatment. Tell your healthcare provider right away if you develop any signs and symptoms of CRS during treatment with TZIELD.

  • Decrease in white blood cells. TZIELD may cause a decrease in a type of white blood cell called lymphocytes. A decrease in white blood cells is a serious, but common side effect that can affect your body's ability to fight infections.

Your healthcare provider will do blood tests to check your liver and your complete blood counts before you start treatment and during treatment with TZIELD. During and after your treatment with TZIELD, your healthcare provider will check for serious side effects, as well as other side effects, and treat you as needed. Your healthcare provider may temporarily or completely stop your treatment with TZIELD, if you develop liver problems, have a serious infection, or if your blood counts stay too low.

Before or after receiving TZIELD, tell your healthcare provider about all your medical conditions, including if you:

  • have a serious infection or an infection that does not go away or that keeps coming back.
  • have recently received or are scheduled to receive an immunization (vaccine). TZIELD may affect how well a vaccine works. Tell your healthcare provider that you are receiving treatment with TZIELD before receiving a vaccine.
  • are pregnant or plan to become pregnant. TZIELD may harm your unborn baby. Do not receive TZIELD during pregnancy and at least 30 days before a planned pregnancy.
  • are breastfeeding or plan to breast feed. It is not known if TZIELD passes into your breast milk and if it can harm your baby. Talk to your healthcare provider about the best way to feed your baby if you receive TZIELD. If you are breastfeeding, you may consider pumping and throwing away your breast milk during treatment with TZIELD and for 20 days after receiving TZIELD treatment.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of TZIELD?

The most common side effects of TZIELD include:

  • rash
  • leukopenia (decrease in white blood cell counts)
  • headache

These are not all of the possible side effects of TZIELD. For more information, ask your healthcare provider or pharmacist. You may report side effects to the FDA at www.fda.gov/medwatch or 1-800-FDA-1088, or to Provention Bio at 1-844-778-2246.

Please see Medication Guide and Prescribing Information. Talk to your doctor about TZIELD.

What is TZIELD?

TZIELD is a prescription medicine used to delay the onset of Stage 3 type 1 diabetes, which is when your body can't make enough insulin on its own and may require insulin injections. TZIELD is for adults and children 8 years of age and older who have Stage 2 type 1 diabetes. This means they have tested positive for 2 or more type 1 diabetes-related autoantibodies, have abnormal blood sugar levels, and do not have type 2 diabetes. It is not known if TZIELD is safe and effective in children under 8 years of age.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about TZIELD?

TZIELD may cause serious side effects, including:

  • Cytokine Release Syndrome (CRS). Signs and symptoms of CRS problems may include:
    • fever
    • feeling tired (fatigue)
    • muscle and joint pain
    • nausea
    • headache
    • increased liver enzymes in your blood

      These signs and symptoms may start during the first 5 days of TZIELD treatment. Tell your healthcare provider right away if you develop any signs and symptoms of CRS during treatment with TZIELD.

  • Decrease in white blood cells. TZIELD may cause a decrease in a type of white blood cell called lymphocytes. A decrease in white blood cells is a serious, but common side effect that can affect your body's ability to fight infections.

Your healthcare provider will do blood tests to check your liver and your complete blood counts before you start treatment and during treatment with TZIELD. During and after your treatment with TZIELD, your healthcare provider will check for serious side effects, as well as other side effects, and treat you as needed. Your healthcare provider may temporarily or completely stop your treatment with TZIELD, if you develop liver problems, have a serious infection, or if your blood counts stay too low.

Before or after receiving TZIELD, tell your healthcare provider about all your medical conditions, including if you:

  • have a serious infection or an infection that does not go away or that keeps coming back.
  • have recently received or are scheduled to receive an immunization (vaccine). TZIELD may affect how well a vaccine works. Tell your healthcare provider that you are receiving treatment with TZIELD before receiving a vaccine.
  • are pregnant or plan to become pregnant. TZIELD may harm your unborn baby. Do not receive TZIELD during pregnancy and at least 30 days before a planned pregnancy.
  • are breastfeeding or plan to breast feed. It is not known if TZIELD passes into your breast milk and if it can harm your baby. Talk to your healthcare provider about the best way to feed your baby if you receive TZIELD. If you are breastfeeding, you may consider pumping and throwing away your breast milk during treatment with TZIELD and for 20 days after receiving TZIELD treatment.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of TZIELD?

The most common side effects of TZIELD include:

  • rash
  • leukopenia (decrease in white blood cell counts)
  • headache

These are not all of the possible side effects of TZIELD. For more information, ask your healthcare provider or pharmacist. You may report side effects to the FDA at www.fda.gov/medwatch or 1-800-FDA-1088, or to Provention Bio at 1-844-778-2246.

Please see Medication Guide and Prescribing Information. Talk to your doctor about TZIELD.

What is TZIELD?

TZIELD is a prescription medicine used to delay the onset of Stage 3 type 1 diabetes, which is when your body can't make enough insulin on its own and may require insulin injections. TZIELD is for adults and children 8 years of age and older who have Stage 2 type 1 diabetes. This means they have tested positive for 2 or more type 1 diabetes-related autoantibodies, have abnormal blood sugar levels, and do not have type 2 diabetes. It is not known if TZIELD is safe and effective in children under 8 years of age.