TZIELD IS
CHANGING THE WAY AUTOIMMUNE TYPE 1 DIABETES IS TREATED

Katie, TZIELD patient with family
Katie, a TZIELD® (teplizumab-mzwv) patient, with her family and dog outdoors

Getting a step ahead is possible—and could help in so many ways

Whether it’s more time learning about the possible complications and what to look out for or planning for the future, being proactive with TZIELD can be a powerful move if your doctor decides it is right for you or your loved one.*

*TZIELD is for people 8 years and older who have Stage 2 type 1 diabetes.

During this time,
people at risk can:

  • Learn more about autoimmune type 1 diabetes and prepare for disease management
  • Identify the right care team, support services, and resources
  • Get more time without the burdens of daily type 1 diabetes management,
    such as glucose monitoring, insulin pump changes, and injections
  • Understand the risk and recognize the signs of potentially serious medical complications that autoimmune type 1 diabetes can cause, such as diabetic ketoacidosis (DKA)
There are currently no studies showing the effect TZIELD has on burden of disease.

Keep in mind:

TZIELD may cause side effects, including serious ones. When studied, the most common side effects for people 8 years and older with Stage 2 autoimmune type 1 diabetes who were given TZIELD included rash, decrease in white blood cell counts (leukopenia), and headache. TZIELD may cause serious side effects, including cytokine release syndrome and a decrease in white blood cells (lymphopenia). See Important Safety Information below and talk to your doctor and wider healthcare team for more information or medical advice about side effects.

Molly: Type 1 diabetes education

Molly was upset to learn her daughter Aubri had type 1 diabetes. But because she worked at a Diabetes Care Center, Molly already knew about TZIELD and was able to delay her daughter’s progression from Stage 2 of T1D to Stage 3.

Molly is an Ambassador sponsored by Sanofi.

Video transcript

TZIELD indication card
Molly VO:
“We are being compensated by Sanofi to share our story.”

Molly, TZILED Caregiver
[Compensated by Sanofi]
“I learned about TZIELD through education at work. I liked that there was a chance that we could potentially delay Stage 3 type 1 diabetes, where Aubri would need insulin.”
[Individual results may vary]
More time before progression
“Thankfully for her, since her infusion, her blood sugars have remained under control. She's still not insulin dependent, and she gets to live like a normal 13-year-old for a little while longer. And not have to deal with the day in and day out struggles of stage 3 type 1 diabetes and being fully insulin dependent. But today, we are both very grateful that she was one of the first to infuse with TZIELD.”

See Molly’s full story on the Real Talk About Type 1 & TZIELD page

[TZIELD logo]

What is TZIELD?
TZIELD is a prescription medicine used to delay the onset of Stage 3 type 1 diabetes, which is when your body can’t make enough insulin on its own and may require insulin injections. TZIELD is for adults and children 8 years of age and older who have Stage 2 type 1 diabetes. This means that they have tested positive for 2 or more type 1 diabetes-related autoantibodies, have abnormal blood sugar levels, and do not have type 2 diabetes.

It is not known if TZIELD is safe and effective in children under 8 years of age.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about TZIELD?

TZIELD may cause serious side effects. These include:

  • Cytokine release syndrome (CRS). Signs and symptoms may start during the first 5 days of TZIELD treatment and could include fever, nausea, feeling tired (fatigue), headache, muscle and joint pain, or increased liver enzymes in your blood. Tell your healthcare provider right away if you develop any signs and symptoms of CRS during treatment with TZIELD
  • Decrease in white blood cells. TZIELD may cause a decrease in a type of white blood cell called lymphocytes. A decrease in white blood cells is a serious, but common side effect that can affect your body’s ability to fight infections. A decrease in white blood cell counts can happen after your first dose. Your white blood cell counts will start to go back to normal after your fifth dose of TZIELD. Some people may develop longer and more severe decreases in lymphocytes

Your healthcare provider will do blood tests to check your liver and your complete blood counts before you start treatment and during treatment with TZIELD. During and after your treatment with TZIELD, your healthcare provider will check for serious side effects, as well as other side effects, and treat you as needed. Your healthcare provider may temporarily or completely stop your treatment with TZIELD, if you develop liver problems, have a serious infection, or if your blood counts stay too low.

What should I tell my healthcare provider before receiving TZIELD?

Before or after receiving TZIELD, tell your healthcare provider about all your medical conditions, including if you:

  • have a serious infection or an infection that does not go away or keeps coming back
  • have recently received or are scheduled to receive an immunization (vaccine). TZIELD may affect how well a vaccine works. Tell your doctor that you are receiving TZIELD before receiving a vaccine
  • are pregnant or plan to become pregnant. TZIELD may harm your unborn baby. Do not receive TZIELD during pregnancy and at least 30 days before a planned pregnancy
  • are breastfeeding or plan to breastfeed. It is not known if TZIELD passes into your breast milk and if it can harm your baby. Talk to your healthcare provider about the best way to feed your baby if you receive TZIELD

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of TZIELD?

The most common side effects of TZIELD include:

  • rash
  • leukopenia (decrease in white blood cell counts)
  • headache

These are not all of the possible side effects of TZIELD. Talk to your healthcare provider for more information, and tell them about any side effects you notice. You may report side effects to the FDA at www.fda.gov/medwatch or 1-800-FDA-1088.

Please see [accompanying] Medication Guide and Prescribing Information.

MAT-US-2306423-v2.0-01/2024

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SEE ALLSEE LESS

With TZIELD, it’s finally possible for appropriate people to take charge of their health earlier and delay the burdens of Stage 3 type 1 diabetes:

A calculator
Counting Carbs
A hand with a droplet over the index finger
Finger Sticks
An insulin vial
Insulin Injections
A dollar sign
Cost of Supplies

There are currently no studies showing the effect TZIELD has on burden of disease.

Casandra, a TZIELD® (teplizumab-mzwv) patient, giving her young daughter a high five at a carnivalCasandra, TZIELD patient with daughter

TZIELD could delay the onset of insulin-dependent type 1 diabetes

A person with autoimmune type 1 diabetes who requires daily insulin may experience as many as 1,860+ finger sticks† and 1,460+ insulin needle injections‡ each and every year.

†If not using a continuous glucose monitor (CGM) vs using a CGM.

‡If using injectable insulin instead of a pump.

There are currently no studies showing the effect TZIELD has on burden of disease.

SCREENING IS THE FIRST STEP

Screening for autoantibodies, staging and monitoring blood glucose levels can help reduce the risk of serious complications of type 1 diabetes. If diagnosed with Stage 2, it's also an opportunity to consider treatment with TZIELD. If you or a loved one hasn’t been screened for autoimmune type 1 diabetes—now is the time. Talk to a doctor today.

Learn why and
how to screen

Be proactive to get ahead on treatment

Discover more about TZIELD and
ask your doctor how delaying the onset of insulin-dependent type 1 diabetes could help
learn more
Ready to talk about TZIELD?
Make the most of a conversation
with this Doctor Discussion Guide
Download
IMPORTANT SAFETY INFORMATION What is the most important information I should know about TZIELD? TZIELD may cause serious side effects. These include:
  • Cytokine release syndrome (CRS). Signs and symptoms may start during the first 5 days of TZIELD treatment and could include fever, nausea, feeling tired (fatigue), headache, muscle and joint pain, or increased liver enzymes in your blood. Tell your healthcare provider right away if you develop any signs and symptoms of CRS during treatment with TZIELD
  • Decrease in white blood cells. TZIELD may cause a decrease in a type of white blood cell called lymphocytes. A decrease in white blood cells is a serious, but common side effect that can affect your body’s ability to fight infections. A decrease in white blood cell counts can happen after your first dose. Your white blood cell counts will start to go back to normal after your fifth dose of TZIELD. Some people may develop longer and more severe decreases in lymphocytes

Your healthcare provider will do blood tests to check your liver and your complete blood counts before you start treatment and during treatment with TZIELD. During and after your treatment with TZIELD, your healthcare provider will check for serious side effects, as well as other side effects, and treat you as needed. Your healthcare provider may temporarily or completely stop your treatment with TZIELD, if you develop liver problems, have a serious infection, or if your blood counts stay too low.

What should I tell my healthcare provider before receiving TZIELD? Before or after receiving TZIELD, tell your healthcare provider about all your medical conditions, including if you:
  • have a serious infection or an infection that does not go away or keeps coming back
  • have recently received or are scheduled to receive an immunization (vaccine). TZIELD may affect how well a vaccine works. Tell your doctor that you are receiving TZIELD before receiving a vaccine
  • are pregnant or plan to become pregnant. TZIELD may harm your unborn baby. Do not receive TZIELD during pregnancy and at least 30 days before a planned pregnancy
  • are breastfeeding or plan to breastfeed. It is not known if TZIELD passes into your breast milk and if it can harm your baby. Talk to your healthcare provider about the best way to feed your baby if you receive TZIELD

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of TZIELD? The most common side effects of TZIELD include:
  • rash
  • leukopenia (decrease in white blood cell counts)
  • headache

These are not all of the possible side effects of TZIELD. Talk to your healthcare provider for more information, and tell them about any side effects you notice. You may report side effects to the FDA at www.fda.gov/medwatch or 1-800-FDA-1088.

Please see Medication Guide and Prescribing Information.

What is TZIELD?

TZIELD is a prescription medicine used to delay the onset of Stage 3 type 1 diabetes, which is when your body can’t make enough insulin on its own and may require insulin injections. TZIELD is for adults and children 8 years of age and older who have Stage 2 type 1 diabetes. This means that they have tested positive for 2 or more type 1 diabetes-related autoantibodies, have abnormal blood sugar levels, and do not have type 2 diabetes.

It is not known if TZIELD is safe and effective in children under 8 years of age.

IMPORTANT SAFETY INFORMATION AND APPROVED USE

What is the most important information I should know about TZIELD? TZIELD may cause serious side effects. These include:
  • Cytokine release syndrome (CRS). Signs and symptoms may start during the first 5 days of TZIELD treatment and could include fever, nausea, feeling tired (fatigue), headache, muscle and joint pain, or increased liver enzymes in your blood. Tell your healthcare provider right away if you develop any signs and symptoms of CRS during treatment with TZIELD
  • Decrease in white blood cells. TZIELD may cause a decrease in a type of white blood cell called lymphocytes. A decrease in white blood cells is a serious, but common side effect that can affect your body’s ability to fight infections. A decrease in white blood cell counts can happen after your first dose. Your white blood cell counts will start to go back to normal after your fifth dose of TZIELD. Some people may develop longer and more severe decreases in lymphocytes

Your healthcare provider will do blood tests to check your liver and your complete blood counts before you start treatment and during treatment with TZIELD. During and after your treatment with TZIELD, your healthcare provider will check for serious side effects, as well as other side effects, and treat you as needed. Your healthcare provider may temporarily or completely stop your treatment with TZIELD, if you develop liver problems, have a serious infection, or if your blood counts stay too low.

What should I tell my healthcare provider before receiving TZIELD? Before or after receiving TZIELD, tell your healthcare provider about all your medical conditions, including if you:
  • have a serious infection or an infection that does not go away or keeps coming back
  • have recently received or are scheduled to receive an immunization (vaccine). TZIELD may affect how well a vaccine works. Tell your doctor that you are receiving TZIELD before receiving a vaccine
  • are pregnant or plan to become pregnant. TZIELD may harm your unborn baby. Do not receive TZIELD during pregnancy and at least 30 days before a planned pregnancy
  • are breastfeeding or plan to breastfeed. It is not known if TZIELD passes into your breast milk and if it can harm your baby. Talk to your healthcare provider about the best way to feed your baby if you receive TZIELD

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of TZIELD? The most common side effects of TZIELD include:
  • rash
  • leukopenia (decrease in white blood cell counts)
  • headache

These are not all of the possible side effects of TZIELD. Talk to your healthcare provider for more information, and tell them about any side effects you notice. You may report side effects to the FDA at www.fda.gov/medwatch or 1-800-FDA-1088.

Please see Medication Guide and Prescribing Information.

What is TZIELD?

TZIELD is a prescription medicine used to delay the onset of Stage 3 type 1 diabetes, which is when your body can’t make enough insulin on its own and may require insulin injections. TZIELD is for adults and children 8 years of age and older who have Stage 2 type 1 diabetes. This means that they have tested positive for 2 or more type 1 diabetes-related autoantibodies, have abnormal blood sugar levels, and do not have type 2 diabetes.

It is not known if TZIELD is safe and effective in children under 8 years of age.